Sand deposit will be formedinside of subsea multiphase pipeline after operating for a period of time, which will lead to diminution of passable area, reduction of inhibitor efficiency, acceleration of corrosion, and even cause the PIG block accidents. In this article, the geometrical model and physical model with field dataare set up building upon the subsea multiphase pipeline from platform A to B in a group of offshore oil and gas fields.Numerical simulations by FLUENT are performed in order to study the sand depositional rule of straight section and bend section according to the variation of parameters such as sand content, particle size, density and flow rate. The research shows that sand depositional amount is positive correlative with and content, particle size, density and negative with flow rate, and the rule of sand depositional maximum position is opposite. The sensitivity of parameters to average sand depositional amount is sand content, flow rate, particle size and density from high to low.